In vitro tests have determined that gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. Inflammation can increase percutaneous absorption.Microbiology Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of pathogenic Gram-negative and Gram-positive bacteria. Topical corticosteroids can be absorbed from normal, intact skin. Clotrimazole is very poorly absorbed following dermal application.Betamethasone valerate, the 17-valerate ester of betamethasone, has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid responsive otitis externa. These events began rapidly and extensively after addition of the drug. In studies of the mechanism of action, the minimum fungicidal concentration of clotrimazole caused leakage of intracellular phosphorus compounds into the ambient medium with concomitant breakdown of cellular nucleic acids and accelerated potassium efflux. mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida sp., and Malassezia pachydermatis (formerly Pityrosporum canis ).Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, T. The primary action of clotrimazole is against dividing and growing organisms. Administration to food producing animals or to pregnant or lactating animals.Ĭlotrimazole is a broad spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes and yeasts. Concomitant use of drugs known to induce ototoxicity should be avoided. pachydermatis) and/or bacteria susceptible to gentamicin.Īdministration to dogs with known perforation of the eardrum (tympanic membrane). Treatment of canine acute and chronic otitis externa associated with yeast (M. gentamicin base 3409 IU/ml,īetamethasone valerate equiv.

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